Following the 2-0 defeat to Wolves before the international break, Russell Martin has made five changes to his Southampton side.
Injured duo Aaron Ramsdale and Jan Bednarek miss out altogether, while Ryan Manning, Joe Aribo and Cameron Archer drop to the bench.
Alex McCarthy comes in in goal, with Ryan Fraser, Flynn Downes, Tyler Dibling and Paul Onuachu returning to the starting line-up.
Liverpool boss Arne Slot makes three changes for the trip to St Mary’s, with Conor Bradley replacing Trent Alexander-Arnold at right-back and Dominik Szoboszlai and Cody Gakpo in for Alexis Mac Allister and Luis Diaz.
Starting XI: Kelleher, Bradley, Konate, Van Dijk, Robertson, Gravenberch, Jones, Salah, Szoboszlai, Gakpo, Nunez.
Subs: Jaros, Davies, Gomez, Enzo, Diaz, Mac Allister, Elliott, Quansah, Morton.
Starting XI: McCarthy, Walker-Peters, Harwood-Bellis, Stephens, Fraser, Downes, Lallana, Fernandes, Dibling, Armstrong, Onuachu.
Subs: Lumley, Sugawara, Bree, Manning, Ugochukwu, Aribo, Kamaldeen, Brereton Diaz, Archer.