Sheffield United manager Chris Wilder has made two alterations to the side that lost 1-0 at Wolves last time out.
The home side have brought back striker Ollie McBurnie to lead the line, while Tom Davies – after a long injury layoff due to a thigh problem that needed surgery – is also handed a start, the midfielder’s first for the club since moving from Everton last summer.
Meanwhile, both Yasser Larouci and Rhian Brewster are benched.
Arsenal are unchanged from the team that beat Newcastle 4-1 nine days ago. That means Jorginho and Declan Rice both start in midfield, with Kai Havertz staying up front.
The big news on the bench is that Thomas Partey is back on the bench after being out since October with injury. Gabriel Jesus is also on the bench after being unused against Newcastle.
Arsenal team news
Team to play Sheffield United: Raya; White, Saliba, Gabriel, Kiwior; Rice, Jorginho, Odegaard; Saka, Havertz, Martinelli
Substitutes: Ramsdale, Cedric, Vieira, Partey, Smith Rowe, Nelson, Trossard, Jesus, Nketiah
Sheff Utd team news
Team to play Arsenal: Grbic, Ahmedhodzic, Trusty, Robinson, Bogle, Norwood, Vinicius Souza, Hamer, Tom Davies, McAtee, McBurnie
Subs: Baldock, Brereton, Foderingham, Osborn, Arblaster, Larouci, Osula, Brooks, Peck