Jack Grealish misses out for Manchester City with a groin injury that could keep him out for a month.
It is one of five changes to Pep Guardiola‘s team from the side that beat Luton in the FA Cup on Tuesday.
Ederson, Ruben Dias, Jeremy Doku. Rodri, and Phil Foden, wth Josko Gvardiol back on the bench after recovering from an ankle injury.
Manchester City XI: Ederson, Walker, Dias, Stones, Ake, Haaland, Doku, Rodri, De Bruyne, Bernardo, Foden.
Substitutes: Ortega, Kovacic, Alvarez, Gomez, Gvardiol, Akanji, Nunes, Bobb, Lewis.
Veteran defender Jonny Evans starts for Manchester United as Harry Maguire remains sidelined with a knee problem.
Youngster Kobbie Mainoo also returns, with Sofyan Amrabat and Antony on the bench from the side that won in the FA Cup on Wednesday.
Manchester United XI: Onana, Lindelof, Fernandes, Rashford, Garnacho, Casemiro, Varane, Dalot, Evans, Mainoo, McTominay.
Substitutes: Bayindir, Amrabat, Eriksen, Amad, Antony, Kambwala, Forson, Collyer, Ogunneye.