Erling Haaland, Mateo Kovacic and Kevin De Bruyne all drop to the Manchester City bench as Pep Guardiola makes four changes to the team that drew 0-0 with Arsenal last time out.
Jack Grealish, Jeremy Doku, Julian Alvarez and Rico Lewis are given start.
Nathan Ake is out nursing an injury. John Stones, who picked up a knock on England duty, is among the City substitutes.
Manchester City XI: Ortega; Akanji, Ruben Dias, Gvardiol, Lewis; Bernado Silva, Grealish, Rodri, Foden, Doku; Alvarez.
Subs: Carson, Stones, Kovacic, Haaland, De Bruyne, Gómez, Nunes, Bobb, Susoho.
As for Aston Villa, Unai Emery makes five changes to the team that beat Wolves 2-0 on Saturday.
Lucas Digne, Clement Lenglet, Nicolo Zaniolo, Jhon Duran and Tim Iroegbunam all start.
Ollie Watkins is sidelined with a hamstring issue. Pau Torres, Alex Moreno, Youri Tielemans and Leon Bailey all drop to the bench.
Aston Villa XI: Martinez; Konsa, Diego Carlos, Lenglet, Digne; Zaniolo, Iroegbunam, Douglas Luiz, Rogers; Diaby, Duran.
Subs: Gauci, Olsen, Tielemans, Pau Torres, Moreno, Chambers, Kesler-Hayden, Bailey, Kellyman.
