Fit again Ibrahima Konate replaces Joe Gomez in the only change to the Liverpool side that thrashed West Ham a week ago.
Conor Bradley has also been reinstated to the bench.
Ruben Amorim makes three changes to the team beaten by Newcastle, one of them made in the first half of that game.
Kobbie Mainoo is in from the start with Joshua Zirkzee dropping out.
Casemiro and Christian Eriksen also make way as Bruno Fernandes and Manuel Ugarte return from suspension.
Liverpool team news
Liverpool team: Alisson, Van Dijk, Konate, Robertson, Alexander-Arnold, Gravenberch, Mac Allister, Jones, Gakpo, Salah, Diaz.
Man Utd team news
Man Utd team: Onana, Mazraoui, De Ligt, Maguire, Martinez, Ugarte, Mainoo, Dalot, Amad, Fernandes, Hojlund.
