Pep Guardiola changes four from the weekend’s Premier League outing against Brentford.
John Stones and Kyle Walker drop out of the back four, replaced by Ruben Dias and Josko Gvardiol.
While in midfield, Mateo Kovacic and Ilkay Gundogan make way for the more familiar pairing or Bernardo and Rodri.
Phil Foden and Jeremy Doku are both available from the bench.
Inter team news
Team to play Man City: Sommer, Bisseck, Acerbi, Bastoni, Darmian, Barella, Calhanoglu, Zielinski, Augusto, Taremi, Thuram.
Subs: Di Gennaro, Martinez, Dumfries, De Vrij, Martinez, Frattesi, Asllani, Mkhitaryan, Pavard.
Man City team news
Man City team to face Inter: Ederson, Lewis, Akanji, Dias, Gvardiol, Rodrigo, De Bruyne, Bernardo, Savinho, Grealish, Haaland.
Subs: Ortega Moreno, Carson, Walker, Stones, Kovacic, Doku, Gundogan, Nunes, Foden, McAtee.