Arsenal have made three changes from the team who lost to Newcastle in the Carabao Cup semi-final in midweek.
Declan Rice and Thomas Partey both drop to the bench with Jorginho and Mikel Merino starting.
The other change sees Gabriel Jesus return to the starting line-up, in place of Leandro Trossard.
Riccardo Calafiori, meanwhile, misses out for Arsenal altogether with a muscle injury, with Myles Lewis-Skelly preferred to Oleksandr Zinchenko once again.
Man Utd have made two changes from the side which drew at Liverpool last weekend, with Alejandro Garnacho starting – despite speculation linking him with a move away from the club.
He comes in for Amad Diallo, who drops to the bench, while, as Ruben Amorim revealed in his pre-match press conference, Altay Bayindir starts in goal in place of Andre Onana.
Arsenal team news
Team to play Man Utd: Raya; Timber, Saliba, Gabriel, Lewis-Skelly; Jorginho, Merino, Odegaard; Jesus, Havertz, Martinelli
Subs: Neto, Tierney, Partey, Kiwior, Zinchenko, Trossard, Sterling, Butler-Oyedeji, Rice
Man Utd team news
Team to play Arsenal: Bayindir, Mazraoui, De Ligt, Maguire, Martinez, Ugarte, Mainoo, Dalot, Garnacho, Fernandes, Hojlund.
Subs: Onana, Zirkzee, Malacia, Eriksen, Yoro, Amad, Casemiro, Antony, Collyer.
